Abstract
Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H(2)O(2)-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / administration & dosage
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Antioxidants / pharmacology*
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Fatty Acid-Binding Proteins / drug effects
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Fatty Acid-Binding Proteins / metabolism
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Fatty Acids / metabolism
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Hydrogen Peroxide / metabolism
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Insulin / blood
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Liver / drug effects
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Liver / metabolism
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Male
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Malondialdehyde / blood
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Obesity / drug therapy*
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Obesity / physiopathology
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Oxidative Stress / drug effects*
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RNA, Messenger / drug effects
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RNA, Messenger / metabolism
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Rats
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Rats, Zucker
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Sulfides / administration & dosage
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Sulfides / pharmacology*
Substances
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Antioxidants
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Fatty Acid-Binding Proteins
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Fatty Acids
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Insulin
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RNA, Messenger
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Sulfides
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Malondialdehyde
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1-(carboxymethylthio)tetradecane
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Hydrogen Peroxide