Long term treatment with tetradecylthioacetic acid improves the antioxidant status in obese Zucker (fa/fa) rats

Drug Metab Lett. 2008 Apr;2(2):138-45. doi: 10.2174/187231208784041013.

Abstract

Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H(2)O(2)-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology*
  • Fatty Acid-Binding Proteins / drug effects
  • Fatty Acid-Binding Proteins / metabolism
  • Fatty Acids / metabolism
  • Hydrogen Peroxide / metabolism
  • Insulin / blood
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Malondialdehyde / blood
  • Obesity / drug therapy*
  • Obesity / physiopathology
  • Oxidative Stress / drug effects*
  • RNA, Messenger / drug effects
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Zucker
  • Sulfides / administration & dosage
  • Sulfides / pharmacology*

Substances

  • Antioxidants
  • Fatty Acid-Binding Proteins
  • Fatty Acids
  • Insulin
  • RNA, Messenger
  • Sulfides
  • Malondialdehyde
  • 1-(carboxymethylthio)tetradecane
  • Hydrogen Peroxide