Four spatial points that define enzyme families

Gábor Iván; Zoltán Szabadka; Rafael Ordög; Vince Grolmusz; Gábor Náray-Szabó

doi:10.1016/j.bbrc.2009.04.022

Four spatial points that define enzyme families

Biochem Biophys Res Commun. 2009 Jun 12;383(4):417-20. doi: 10.1016/j.bbrc.2009.04.022. Epub 2009 Apr 11.

Authors

Gábor Iván¹, Zoltán Szabadka, Rafael Ordög, Vince Grolmusz, Gábor Náray-Szabó

Affiliation

¹ Protein Information Technology Group, Eötvös University, 1117 Budapest, Hungary.

PMID: 19364497
DOI: 10.1016/j.bbrc.2009.04.022

Abstract

The catalytic properties of enzymes, containing the Asp-His-Ser triads are deeply investigated for a long time. Serine endopeptidases, cutinases, acetylcholinesterases, cellulases, among other enzymes, contain these triads. We found that solely the geometric properties of just four points in the spatial structure of these enzymes are characteristic to their family.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Aspartic Acid / chemistry*
Catalysis
Databases, Protein
Enzymes / chemistry*
Enzymes / classification*
Histidine / chemistry*
Protein Conformation
Serine / chemistry*

Substances

Enzymes
Aspartic Acid
Serine
Histidine