Multiple target regulation by small noncoding RNAs rewires gene expression at the post-transcriptional level

Kai Papenfort; Jörg Vogel

doi:10.1016/j.resmic.2009.03.004

Multiple target regulation by small noncoding RNAs rewires gene expression at the post-transcriptional level

Res Microbiol. 2009 May;160(4):278-87. doi: 10.1016/j.resmic.2009.03.004. Epub 2009 Apr 12.

Authors

Kai Papenfort¹, Jörg Vogel

Affiliation

¹ Max Planck Institute for Infection Biology, RNA Biology Group, Charitéplatz 1, 10117 Berlin, Germany.

PMID: 19366629
DOI: 10.1016/j.resmic.2009.03.004

Abstract

Small noncoding RNAs (sRNAs), often in conjunction with Hfq protein, have increasingly been shown to regulate multiple rather than individual mRNAs, thereby reprogramming gene expression at the post-transcriptional level. This review summarizes how and when several such regulators (CyaR, DsrA, GcvB, OmrAB, RNAIII, RybB, RyhB) act upon multiple targets.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bacteria / metabolism
Escherichia coli Proteins / metabolism
Gene Expression Regulation, Bacterial*
Host Factor 1 Protein / metabolism
RNA Processing, Post-Transcriptional*
RNA, Bacterial / physiology
RNA, Messenger / metabolism
RNA, Untranslated / physiology*
Stress, Physiological / genetics

Substances

Escherichia coli Proteins
Hfq protein, E coli
Host Factor 1 Protein
RNA, Bacterial
RNA, Messenger
RNA, Untranslated