Abstract
All in a knot. The smallest riboswitch forms a pseudoknot in solution. This is demonstrated for preQ(1) class I aptamers by mutational analysis in combination with (1)H NMR-based structure probing. How pseudoknot formation mediates the mRNA response through its expression platform is now open for investigation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5' Untranslated Regions*
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Aptamers, Nucleotide / chemistry*
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Aptamers, Nucleotide / metabolism
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Base Pairing
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Base Sequence
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Fusobacterium nucleatum / genetics
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Fusobacterium nucleatum / metabolism
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Mutation
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Nucleic Acid Conformation
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Pyrimidinones / chemistry*
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Pyrimidinones / metabolism
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Pyrroles / chemistry*
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Pyrroles / metabolism
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RNA, Bacterial / chemistry
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RNA, Bacterial / metabolism
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RNA, Transfer / chemistry
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RNA, Transfer / metabolism
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Regulatory Sequences, Ribonucleic Acid*
Substances
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5' Untranslated Regions
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7-(aminomethyl)-7-deazaguanine
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Aptamers, Nucleotide
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Pyrimidinones
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Pyrroles
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RNA, Bacterial
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Regulatory Sequences, Ribonucleic Acid
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RNA, Transfer