Evidence for pseudoknot formation of class I preQ1 riboswitch aptamers

Chembiochem. 2009 May 4;10(7):1141-4. doi: 10.1002/cbic.200900155.

Abstract

All in a knot. The smallest riboswitch forms a pseudoknot in solution. This is demonstrated for preQ(1) class I aptamers by mutational analysis in combination with (1)H NMR-based structure probing. How pseudoknot formation mediates the mRNA response through its expression platform is now open for investigation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5' Untranslated Regions*
  • Aptamers, Nucleotide / chemistry*
  • Aptamers, Nucleotide / metabolism
  • Base Pairing
  • Base Sequence
  • Fusobacterium nucleatum / genetics
  • Fusobacterium nucleatum / metabolism
  • Mutation
  • Nucleic Acid Conformation
  • Pyrimidinones / chemistry*
  • Pyrimidinones / metabolism
  • Pyrroles / chemistry*
  • Pyrroles / metabolism
  • RNA, Bacterial / chemistry
  • RNA, Bacterial / metabolism
  • RNA, Transfer / chemistry
  • RNA, Transfer / metabolism
  • Regulatory Sequences, Ribonucleic Acid*

Substances

  • 5' Untranslated Regions
  • 7-(aminomethyl)-7-deazaguanine
  • Aptamers, Nucleotide
  • Pyrimidinones
  • Pyrroles
  • RNA, Bacterial
  • Regulatory Sequences, Ribonucleic Acid
  • RNA, Transfer