Adjuncts for ovarian stimulation: when do we adopt "orphan indications" for approved drugs?

Fertil Steril. 2009 Jul;92(1):13-8. doi: 10.1016/j.fertnstert.2009.03.081. Epub 2009 May 6.

Abstract

Several drugs, shown to be safe for other uses, have proven to be highly effective adjuncts for ovarian stimulation. The authors evaluate these "orphan" indications and make recommendations so that more patients will benefit from their use.

MeSH terms

  • Androgens / therapeutic use
  • Aspirin / therapeutic use
  • Contraceptives, Oral / therapeutic use
  • Dopamine Agonists / therapeutic use
  • Estrogens / therapeutic use
  • Female
  • Fertilization in Vitro / methods
  • Human Growth Hormone / therapeutic use
  • Humans
  • Leuprolide / therapeutic use
  • Metformin / therapeutic use
  • Orphan Drug Production / statistics & numerical data*
  • Ovulation Induction / methods*
  • Polycystic Ovary Syndrome / drug therapy*

Substances

  • Androgens
  • Contraceptives, Oral
  • Dopamine Agonists
  • Estrogens
  • Human Growth Hormone
  • Metformin
  • Leuprolide
  • Aspirin