Additional genes which result in an elevation of acetylcholine levels by mutations in Caenorhabditis elegans

R Hosono; Y Kamiya

doi:10.1016/0304-3940(91)90270-4

Additional genes which result in an elevation of acetylcholine levels by mutations in Caenorhabditis elegans

Neurosci Lett. 1991 Jul 22;128(2):243-4. doi: 10.1016/0304-3940(91)90270-4.

Authors

R Hosono¹, Y Kamiya

Affiliation

¹ Department of Biochemistry, School of Medicine, Kanazawa University, Japan.

PMID: 1945043
DOI: 10.1016/0304-3940(91)90270-4

Abstract

Four mutant genes (unc-17, unc-18, unc-41 and unc-13) have been identified that result in abnormal accumulation of acetylcholine (ACh). We have now identified 3 more such genes (unc-63, unc-11 and unc-64). In addition to the abnormal accumulation of ACh, mutants in these 7 genes possess common phenotypes in locomotion, resistance to inhibitors of acetylcholinesterase (AChE) and in post-embryonic development. These results suggest that the 7 genes are involved in some related functions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylcholine / metabolism*
Animals
Caenorhabditis / genetics*
Genotype
Mutation
Phenotype
Trichlorfon / pharmacology

Substances

Trichlorfon
Acetylcholine