Occurence and bioactivities of funicone-related compounds

Int J Mol Sci. 2009 Mar 30;10(4):1430-1444. doi: 10.3390/ijms10041430.

Abstract

Studies on production of secondary metabolites by fungi have received a substantial boost lately, particularly with reference to applications of their biological properties in human medicine. Funicones represent a series of related compounds for which there is accumulating evidence supporting their possible use as pharmaceuticals. This paper provides a review on the current status of knowledge on these fungal extrolites, with special reference to aspects concerning their molecular structures and biological activities.

Keywords: Biological activity; Penicillium; chemotaxonomy; fungal extrolites; funicones.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / toxicity
  • Bacteria / drug effects
  • Cell Proliferation / drug effects
  • Fungi / drug effects
  • Fungi / metabolism
  • Humans
  • Penicillium / metabolism
  • Pyrones / chemistry*

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Antineoplastic Agents
  • Pyrones