Abstract
The action of dopamine and other monoamine neurotransmitters at synapses is terminated predominantly by high-affinity reuptake into presynaptic terminals by specific sodium-dependent neurotransmitter transport proteins. A complementary DNA encoding a rat dopamine transporter has been isolated that exhibits high sequence similarity with the previously cloned norepinephrine and gamma-aminobutyric acid transporters. Transient expression of the complementary DNA in HeLa cells confirms the cocaine sensitivity of this transporter.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Carrier Proteins / drug effects
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Carrier Proteins / genetics*
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Carrier Proteins / metabolism
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Cloning, Molecular
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Cocaine / pharmacology*
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Dopamine / metabolism*
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Dopamine Plasma Membrane Transport Proteins
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Gene Expression
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HeLa Cells
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Humans
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Kinetics
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Membrane Glycoproteins*
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Membrane Transport Proteins*
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Molecular Sequence Data
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Nerve Tissue Proteins*
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Oligodeoxyribonucleotides
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Polymerase Chain Reaction / methods
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Rats
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Sequence Homology, Nucleic Acid
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Transfection
Substances
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Carrier Proteins
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Dopamine Plasma Membrane Transport Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Oligodeoxyribonucleotides
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Cocaine
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Dopamine
Associated data
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GENBANK/M76239
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GENBANK/M76240
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GENBANK/M76241
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GENBANK/M76242
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GENBANK/M76243
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GENBANK/M76244
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GENBANK/M80233
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GENBANK/M83741
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GENBANK/M83742
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GENBANK/S70464