MHC class I antigen presentation: learning from viral evasion strategies

Nat Rev Immunol. 2009 Jul;9(7):503-13. doi: 10.1038/nri2575.

Abstract

The cell surface display of peptides by MHC class I molecules to lymphocytes provides the host with an important surveillance mechanism to protect against invading pathogens. However, in turn, viruses have evolved elegant strategies to inhibit various stages of the MHC class I antigen presentation pathway and prevent the display of viral peptides. This Review highlights how the elucidation of mechanisms of viral immune evasion is important for advancing our understanding of virus-host interactions and can further our knowledge of the MHC class I presentation pathway as well as other cellular pathways.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / immunology
  • ATP-Binding Cassette Transporters / metabolism
  • Animals
  • Antigen Presentation*
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism
  • B-Lymphocytes / virology
  • Enzyme Inhibitors / immunology
  • Enzyme Inhibitors / metabolism
  • Histocompatibility Antigens Class I / immunology*
  • Histocompatibility Antigens Class I / metabolism
  • Humans
  • Membrane Transport Proteins / immunology
  • Membrane Transport Proteins / metabolism
  • Proteasome Endopeptidase Complex / immunology
  • Proteasome Endopeptidase Complex / metabolism
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism
  • T-Lymphocytes / virology
  • Ubiquitin / immunology
  • Ubiquitin / metabolism
  • Ubiquitin-Protein Ligases / immunology
  • Ubiquitin-Protein Ligases / metabolism
  • Viral Proteins / immunology*
  • Viral Proteins / metabolism
  • Viruses / immunology*

Substances

  • ATP-Binding Cassette Transporters
  • Enzyme Inhibitors
  • Histocompatibility Antigens Class I
  • Membrane Transport Proteins
  • Ubiquitin
  • Viral Proteins
  • tapasin
  • Ubiquitin-Protein Ligases
  • Proteasome Endopeptidase Complex