Actin-based protrusions: promoters or inhibitors of cancer invasion?

Cancer Cell. 2009 Jul 7;16(1):5-7. doi: 10.1016/j.ccr.2009.06.009.

Abstract

In a recent issue of Cell, Silva and colleagues reported the identification of CYFIP1, a member of the actin-assembly-promoting Scar/WAVE complex, as an invasion suppressor in epithelial cancers. This study challenges ideas about the role of actin in cancer invasion.

Publication types

  • Comment

MeSH terms

  • Actins / metabolism*
  • Animals
  • Cell Line, Tumor
  • Hedgehog Proteins / antagonists & inhibitors
  • Hedgehog Proteins / physiology
  • Humans
  • Magnetic Resonance Imaging
  • Mice
  • Mutation
  • Neoplasm Invasiveness
  • Pancreatic Neoplasms / epidemiology
  • Pancreatic Neoplasms / genetics
  • Pancreatic Neoplasms / mortality
  • Pancreatic Neoplasms / pathology*
  • Perfusion
  • Signal Transduction
  • Survival Analysis
  • United States / epidemiology
  • Veratrum Alkaloids / therapeutic use

Substances

  • Actins
  • Hedgehog Proteins
  • IPI-926
  • Veratrum Alkaloids