Abstract
In a recent issue of Cell, Silva and colleagues reported the identification of CYFIP1, a member of the actin-assembly-promoting Scar/WAVE complex, as an invasion suppressor in epithelial cancers. This study challenges ideas about the role of actin in cancer invasion.
MeSH terms
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Actins / metabolism*
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Animals
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Cell Line, Tumor
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Hedgehog Proteins / antagonists & inhibitors
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Hedgehog Proteins / physiology
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Humans
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Magnetic Resonance Imaging
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Mice
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Mutation
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Neoplasm Invasiveness
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Pancreatic Neoplasms / epidemiology
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Pancreatic Neoplasms / genetics
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Pancreatic Neoplasms / mortality
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Pancreatic Neoplasms / pathology*
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Perfusion
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Signal Transduction
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Survival Analysis
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United States / epidemiology
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Veratrum Alkaloids / therapeutic use
Substances
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Actins
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Hedgehog Proteins
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IPI-926
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Veratrum Alkaloids