Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor

Angew Chem Int Ed Engl. 2009;48(34):6346-9. doi: 10.1002/anie.200901647.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Aldehydes / pharmacology
  • Caspase 3 / metabolism
  • Caspase Inhibitors*
  • Cysteine Proteinase Inhibitors / chemistry*
  • Cysteine Proteinase Inhibitors / pharmacology
  • Drug Evaluation, Preclinical
  • Fluorescence Polarization
  • Protein Binding

Substances

  • Aldehydes
  • Caspase Inhibitors
  • Cysteine Proteinase Inhibitors
  • Caspase 3