This paper is about Christopher Wren's engravings for Thomas Willis' The Anatomy of the Brain and Nerves of 1664. It is a study in the intersection of medicine and art in 17th century Britain. Willis, an eminent English physician and anatomist, was a major figure in the development of modern neurology, and The Anatomy of the Brain and Nerves was his most famous and influential book. Wren was Willis' assistant and medical artist. I discuss the visual strategies employed by Wren to present their research and frame it as genuine knowledge.