Abstract
While the role of endogenous T cells in antitumor immunity is being debated, little is known about whether and how T cells promote tumorigenesis. In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion.
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / physiology*
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Disease Models, Animal
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Female
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Interleukin-4 / metabolism*
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Interleukin-4 / physiology
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Lung Neoplasms / immunology
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Lung Neoplasms / secondary*
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Lymphocyte Activation
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Macrophages / metabolism*
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Macrophages / physiology
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Mammary Neoplasms, Experimental / immunology
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Mammary Neoplasms, Experimental / pathology*
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Mice
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Models, Immunological
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Signal Transduction