The laboratory approach to inherited and acquired coagulation factor deficiencies

Benjamin L Wagenman; Kelly T Townsend; Prasad Mathew; Kendall P Crookston

doi:10.1016/j.cll.2009.04.002

The laboratory approach to inherited and acquired coagulation factor deficiencies

Clin Lab Med. 2009 Jun;29(2):229-52. doi: 10.1016/j.cll.2009.04.002.

Authors

Benjamin L Wagenman¹, Kelly T Townsend, Prasad Mathew, Kendall P Crookston

Affiliation

¹ Department of Pathology, University of New Mexico, TriCore Reference Laboratories, 915 Camino de Salud NE, Albuquerque, NM 87102, USA.

PMID: 19665676
DOI: 10.1016/j.cll.2009.04.002

Abstract

Besides the long-recognized hemophilias, there are many other factor deficiencies. Some also are inherited, but others are acquired because of both immune and nonimmune etiologies. Understanding the optimal laboratory approach to evaluating factor deficiency will aid physicians and laboratory scientists in obtaining a prompt diagnosis and in avoiding pitfalls in coagulation testing.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Blood Coagulation Disorders / blood
Blood Coagulation Disorders / diagnosis*
Blood Coagulation Disorders / genetics
Blood Coagulation Factors / analysis*
Blood Coagulation Tests / methods*
Blood Coagulation Tests / standards
Hemophilia A / diagnosis
Hemophilia A / genetics
Humans
Hypoprothrombinemias / diagnosis
Hypoprothrombinemias / genetics

Substances

Blood Coagulation Factors