Modulation of inflammation through IL-17 production by gammadelta T cells: mandatory in the mouse, dispensable in humans?

Florence Deknuydt; Emmanuel Scotet; Marc Bonneville

doi:10.1016/j.imlet.2009.08.003

Modulation of inflammation through IL-17 production by gammadelta T cells: mandatory in the mouse, dispensable in humans?

Immunol Lett. 2009 Dec 2;127(1):8-12. doi: 10.1016/j.imlet.2009.08.003. Epub 2009 Aug 12.

Authors

Florence Deknuydt¹, Emmanuel Scotet, Marc Bonneville

Affiliation

¹ INSERM, U892, Centre de Recherche en Cancérologie Nantes-Angers, 44007 Nantes, France.

PMID: 19682496
DOI: 10.1016/j.imlet.2009.08.003

Abstract

Recent studies suggest that gammadelta T cells are innate IL-17 producers owing to unique features of their developmental program. A key contribution of this subset to T helper 17 responses has been also suggested by numerous physiopathological studies mainly performed in mouse models. In the present review, we will summarize the main features of IL-17-producing gammadelta T cells and highlight the similarities and differences between murine gammadelta T cells and their human counterparts.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antigens, CD / biosynthesis
Disease Models, Animal
Humans
Immunity, Cellular*
Infections / immunology
Inflammation Mediators / metabolism
Interleukin-17 / biosynthesis*
Interleukin-17 / genetics
Mice
Receptors, Antigen, T-Cell, gamma-delta / metabolism*
T-Cell Antigen Receptor Specificity
T-Lymphocyte Subsets / metabolism*
T-Lymphocyte Subsets / pathology

Substances

Antigens, CD
Inflammation Mediators
Interleukin-17
Receptors, Antigen, T-Cell, gamma-delta