From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development

Nat Immunol. 2009 Sep;10(9):929-32. doi: 10.1038/ni0909-929.

Abstract

The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / physiology*
  • Cell Differentiation
  • Cell Polarity
  • Humans
  • Interferon-gamma / biosynthesis
  • Interleukin-10 / physiology*
  • Interleukin-12 / physiology*
  • Macrophages / physiology
  • Th1 Cells / physiology*
  • Th2 Cells / physiology

Substances

  • Interleukin-10
  • Interleukin-12
  • Interferon-gamma