Abstract
The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.
MeSH terms
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Animals
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Antigen-Presenting Cells / physiology*
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Cell Differentiation
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Cell Polarity
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Humans
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Interferon-gamma / biosynthesis
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Interleukin-10 / physiology*
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Interleukin-12 / physiology*
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Macrophages / physiology
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Th1 Cells / physiology*
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Th2 Cells / physiology
Substances
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Interleukin-10
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Interleukin-12
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Interferon-gamma