Protein conjugates of SH3-domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases

Chembiochem. 2009 Oct 12;10(15):2445-8. doi: 10.1002/cbic.200900462.

Authors

Rakesh Tiwari¹, Keykavous Parang

Affiliation

¹ Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA.

PMID: 19731277
DOI: 10.1002/cbic.200900462

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adenosine Triphosphate / antagonists & inhibitors*
Adenosine Triphosphate / metabolism
Amino Acid Sequence
Binding, Competitive*
Guanine / analogs & derivatives
Guanine / chemistry
Humans
Ligands
O(6)-Methylguanine-DNA Methyltransferase / antagonists & inhibitors
O(6)-Methylguanine-DNA Methyltransferase / chemistry
O(6)-Methylguanine-DNA Methyltransferase / metabolism
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / metabolism*
Protein Kinase Inhibitors / pharmacology*
src Homology Domains*

Substances

Ligands
Protein Kinase Inhibitors
O(6)-benzylguanine
Guanine
Adenosine Triphosphate
O(6)-Methylguanine-DNA Methyltransferase