A molecular link between AKT regulation and chemotherapeutic response

Cancer Cell. 2009 Sep 8;16(3):178-80. doi: 10.1016/j.ccr.2009.08.011.

Abstract

The protein kinase AKT is frequently activated in human cancers and has been implicated in resistance to chemotherapy. In this issue of Cancer Cell, Pei et al. show that FKBP51 negatively regulates AKT through the phosphatase PHLPP. This regulation appears to be a determinant of chemosensitivity in cancer cells.

Publication types

  • Comment

MeSH terms

  • Humans
  • Models, Biological
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Nuclear Proteins / metabolism*
  • Phosphoprotein Phosphatases
  • Phosphorylation
  • Proto-Oncogene Proteins c-akt / physiology*
  • Sensitivity and Specificity
  • Tacrolimus Binding Proteins / metabolism*

Substances

  • Nuclear Proteins
  • Proto-Oncogene Proteins c-akt
  • PHLPP1 protein, human
  • Phosphoprotein Phosphatases
  • Tacrolimus Binding Proteins
  • tacrolimus binding protein 5