Abstract
DNA encoding the human aminopeptidase N (EC 3.4.11.2) gene (PEPN) was first isolated using rat cDNA probes and then used in Southern analysis of DNA from mouse-human somatic cell hybrids to assign this gene to the long-arm region (q11-qter) of human chromosome 15. This human genomic DNA probe detects a frequent DraIII polymorphism that is a useful marker for human chromosome 15.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Aminopeptidases / genetics*
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Animals
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Base Sequence
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Blotting, Southern
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CD13 Antigens
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Cells, Cultured
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Chromosomes, Human, Pair 15
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DNA / isolation & purification*
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Humans
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Hybrid Cells
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In Vitro Techniques
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Mice
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Molecular Sequence Data
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Polymorphism, Genetic*
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Restriction Mapping
Substances
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DNA
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Aminopeptidases
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CD13 Antigens