Design and synthesis of a homogeneous erythropoietin analogue with two human complex-type sialyloligosaccharides: combined use of chemical and bacterial protein expression methods

Angew Chem Int Ed Engl. 2009;48(50):9557-60. doi: 10.1002/anie.200904376.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemical Phenomena
  • Drug Design*
  • Erythropoietin / analogs & derivatives*
  • Erythropoietin / chemistry
  • Escherichia coli / metabolism
  • Humans
  • Oligosaccharides / chemistry*
  • Protein Biosynthesis

Substances

  • Oligosaccharides
  • sialooligosaccharides
  • Erythropoietin