Abstract
Imatinib (trade name Gleevec) preserves fertility in female mice treated with the common chemotherapeutic agent cisplatin. Imatinib seems to block an apoptotic pathway activated by cisplatin in ovarian germ cells (pages 1179– 1185). The findings could lead to new ways to protect germ cells from the damaging effects of cancer treatment.
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use
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Apoptosis / drug effects
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Benzamides
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Cisplatin / therapeutic use
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Female
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Humans
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Imatinib Mesylate
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Infertility, Female / therapy*
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Mice
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Piperazines / therapeutic use*
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Primary Ovarian Insufficiency / therapy*
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Pyrimidines / therapeutic use*
Substances
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Antineoplastic Agents
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Benzamides
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Piperazines
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Pyrimidines
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Imatinib Mesylate
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Cisplatin