The fragmented gene

Ann N Y Acad Sci. 2009 Oct:1178:186-93. doi: 10.1111/j.1749-6632.2009.05004.x.

Abstract

While once almost synonymous, there is an increasing gap between the expanding definition of what constitutes a gene and the conservative and narrowly defined terms code or coding, which for a long time, almost exclusively constituted the open reading frame. Much confusion results from this disparity, especially in light of the plethora of noncoding RNAs (more correctly termed "non-protein-coding RNAs") that usually are encoded and transcribed by their own genes. A simple solution would be to adopt Ed Trifonov's less constrained definition of a code as any sequence pattern that can have a biological function. Such consideration favors not only a more complex view of the gene as an entity composed of many more or less conserved subgenic modules, but also a concept of modular evolution of genes and entire genomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Conserved Sequence
  • Evolution, Molecular*
  • Genome*
  • Humans
  • Open Reading Frames
  • RNA, Untranslated / metabolism*

Substances

  • RNA, Untranslated