Aim: To investigate the expression and the significance of beta-catenin and Cyclin D1 in gliomas.
Methods: The SABC immunohistochemistry were used to detect the expression of beta-catenin and Cyclin D1 in 49 brain gliomas and 5 normal brain tissues.
Results: The beta-catenin positive ratio in normal brain tissues and glioma samples are 2/5 and 38/49(P<0.01) respectively, and the Cyclin D1 positive ratio in normal brain tissues and gliomas are 1/5 and 42/49(P<0.01); Compared with the normal brain tissue, both the immunohistochemical expression of beta-catenin and Cyclin D1 were up-regulated(P<0.05), and the expression of beta-catenin and Cyclin D1 between the normal brain tissues and gliomas exhibited significantly difference (P<0.01).
Conclusion: beta-catenin and Cyclin D1 increased in gliomas may be precipitate the tumorigenesis of glioma.