[Significance of beta-catenin and Cyclin D1 express in glioma]

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Nov;25(11):1010-2.
[Article in Chinese]

Abstract

Aim: To investigate the expression and the significance of beta-catenin and Cyclin D1 in gliomas.

Methods: The SABC immunohistochemistry were used to detect the expression of beta-catenin and Cyclin D1 in 49 brain gliomas and 5 normal brain tissues.

Results: The beta-catenin positive ratio in normal brain tissues and glioma samples are 2/5 and 38/49(P<0.01) respectively, and the Cyclin D1 positive ratio in normal brain tissues and gliomas are 1/5 and 42/49(P<0.01); Compared with the normal brain tissue, both the immunohistochemical expression of beta-catenin and Cyclin D1 were up-regulated(P<0.05), and the expression of beta-catenin and Cyclin D1 between the normal brain tissues and gliomas exhibited significantly difference (P<0.01).

Conclusion: beta-catenin and Cyclin D1 increased in gliomas may be precipitate the tumorigenesis of glioma.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cell Nucleus / metabolism
  • Child
  • Cyclin D1 / metabolism*
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Glioma / genetics*
  • Glioma / metabolism
  • Glioma / pathology
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Up-Regulation
  • Young Adult
  • beta Catenin / metabolism*

Substances

  • beta Catenin
  • Cyclin D1