Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase

J Med Chem. 1991 Jan;34(1):463-6. doi: 10.1021/jm00105a071.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anticholesteremic Agents / chemistry
  • Anticholesteremic Agents / pharmacology*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors*
  • Kinetics
  • Male
  • Microsomes / enzymology
  • Microsomes, Liver / enzymology
  • Molecular Structure
  • Rats
  • Spleen / enzymology
  • Structure-Activity Relationship
  • Testis / enzymology

Substances

  • Anticholesteremic Agents
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors