From information to knowledge: new technologies for defining gene function

Nat Methods. 2009 Oct;6(10):721-23. doi: 10.1038/nmeth1009-721.

Abstract

A wide range of methodology will be needed to bridge the gap between genome sequence and mechanistic understanding in biology. Recent advances in high-throughput genetic screening address this task.

MeSH terms

  • Bacteria
  • Epistasis, Genetic
  • Gene Deletion
  • Genes / genetics
  • Genes / physiology*
  • Genome / genetics*
  • Genome / physiology
  • High-Throughput Screening Assays / methods*
  • Microscopy / methods
  • Mutation
  • Phenotype*
  • Saccharomyces cerevisiae / genetics
  • Sequence Analysis, DNA / methods*
  • Sequence Analysis, DNA / trends