The pressure recovery ratio: The invasive index of LV relaxation during filling. Model-based prediction with in-vivo validation

Annu Int Conf IEEE Eng Med Biol Soc. 2009:2009:3940-3. doi: 10.1109/IEMBS.2009.5333092.

Abstract

Using a simple harmonic oscillator model (PDF formalism), every early filling E-wave can be uniquely described by a set of parameters, (x(0), c, and k). Parameter c in the PDF formalism is a damping or relaxation parameter that measures the energy loss during the filling process. Based on Bernoulli's equation and kinematic modeling, we derived a causal correlation between the relaxation parameter c in the PDF formalism and a feature of the pressure contour during filling - the pressure recovery ratio defined by the left ventricular pressure difference between diastasis and minimum pressure, normalized to the pressure difference between a fiducial pressure and minimum pressure [PRR = (P(Diastasis)-P(Min))/(P(Fiducial)-P(Min))]. We analyzed multiple heart beats from one human subject to validate the correlation. Further validation among more patients is warranted. PRR is the invasive causal analogue of the noninvasive E-wave relaxation parameter c. PRR has the potential to be calculated using automated methodology in the catheterization lab in real time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Biomechanical Phenomena
  • Biophysics / methods
  • Computer Simulation
  • Heart Rate
  • Heart Ventricles / pathology*
  • Hemodynamics
  • Humans
  • Models, Cardiovascular
  • Models, Statistical
  • Myocardial Contraction / physiology*
  • Oscillometry
  • Pressure
  • Time Factors
  • Ultrasonography, Doppler / methods