Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: applications in ratiometric oxygen sensing in vitro and in regioselective cell killing

Chem Commun (Camb). 2009 Dec 21:(47):7321-3. doi: 10.1039/b920222f. Epub 2009 Nov 2.

Abstract

A terbium complex has been designed that may be used to sensitise formation of singlet oxygen (phi(em) 12%), allowing the creation of a ratiometric sensory system for pO(2) (versus the insensitive Eu analogue) and the definition of a reactive probe that can be used to cause local damage to cells loaded with the complex and exposed to laser excitation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / drug effects*
  • Aza Compounds / chemistry*
  • Aza Compounds / pharmacology
  • Mice
  • Molecular Structure
  • NIH 3T3 Cells
  • Naphthols / chemistry*
  • Oxygen / chemistry*
  • Structure-Activity Relationship
  • Terbium / chemistry*
  • Xanthones / chemistry*
  • Xanthones / pharmacology

Substances

  • Aza Compounds
  • Naphthols
  • Xanthones
  • Terbium
  • xanthone
  • Oxygen