Effect of probiotic supplementation in the first 6 months of life on specific antibody responses to infant Hepatitis B vaccination

Vaccine. 2010 Mar 19;28(14):2577-9. doi: 10.1016/j.vaccine.2010.01.020. Epub 2010 Jan 25.

Abstract

Probiotics have been shown to enhance specific immune responses to vaccines. We aim to assess the effect of probiotic supplementation on specific IgG antibody responses to Hepatitis B (HepB) vaccination in infants. Compared to controls, probiotic supplementation improved HepB surface antibody responses in subjects receiving monovalent doses of HepB vaccine at 0, 1 month and a DTPa-HepB combination vaccine at 6 months [placebo (n=28): 187.97 (180.70-195.24), probiotic (n=29): 345.70 (339.41-351.99)mIU/ml] (p=0.069), but not those who received 3 monovalent doses [placebo (n=68): 302.34 (296.31-308.37), probiotic (n=77): 302.06 (296.31-307.81)mIU/ml] (p=0.996). Probiotics may enhance specific antibody responses in infants receiving certain Hepatitis B vaccine schedules.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diphtheria-Tetanus-Pertussis Vaccine / immunology
  • Female
  • Haemophilus Vaccines / immunology
  • Hepatitis B Antibodies / blood*
  • Hepatitis B Vaccines / immunology*
  • Humans
  • Immunoglobulin G / blood
  • Infant
  • Infant, Newborn
  • Male
  • Placebos / administration & dosage
  • Probiotics / administration & dosage*

Substances

  • Diphtheria-Tetanus-Pertussis Vaccine
  • Haemophilus Vaccines
  • Hepatitis B Antibodies
  • Hepatitis B Vaccines
  • Immunoglobulin G
  • Placebos
  • diphtheria-tetanus-acellular pertussis-Hib-hepatitis B vaccine