Lonomia obliqua venom: In vivo effects and molecular aspects associated with the hemorrhagic syndrome

Toxicon. 2010 Dec 15;56(7):1103-12. doi: 10.1016/j.toxicon.2010.01.013. Epub 2010 Jan 28.

Abstract

Caterpillar envenomation has been an emergent health issue. Lonomia obliqua is a medically important animal that causes a hemorrhagic syndrome that can progress to acute renal failure, intracranial hemorrhage and death. In the past few years the molecular characterization of L. obliqua venom in addition to experimental models has provided fundamental information to the understanding of the envenomation syndrome. Herein studies from several authors which characterized the complex toxic-pharmacological actions of whole venom are reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antivenins / therapeutic use
  • Arthropod Venoms / chemistry
  • Arthropod Venoms / toxicity*
  • Blood Coagulation / drug effects
  • Gene Expression Profiling
  • Gene Expression Regulation / drug effects
  • Hemolysis / drug effects
  • Hemorrhagic Disorders / blood
  • Hemorrhagic Disorders / etiology*
  • Hemorrhagic Disorders / therapy
  • Humans
  • Insect Bites and Stings / drug therapy
  • Insect Bites and Stings / pathology
  • Kidney / drug effects
  • Larva / chemistry
  • Larva / genetics
  • Models, Biological
  • Moths / chemistry*
  • Moths / genetics
  • Moths / growth & development
  • Platelet Aggregation / drug effects
  • Syndrome

Substances

  • Antivenins
  • Arthropod Venoms