Current knowledge of the pre-autophagosomal structure (PAS)

Kuninori Suzuki; Yoshinori Ohsumi

doi:10.1016/j.febslet.2010.02.001

Current knowledge of the pre-autophagosomal structure (PAS)

FEBS Lett. 2010 Apr 2;584(7):1280-6. doi: 10.1016/j.febslet.2010.02.001. Epub 2010 Feb 5.

Authors

Kuninori Suzuki¹, Yoshinori Ohsumi

Affiliation

¹ Advanced Research Organization, Integrated Research Institute, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.

PMID: 20138172
DOI: 10.1016/j.febslet.2010.02.001

Abstract

Autophagy is a system for degradation of bulk cellular components in lytic compartments, vacuoles, or lysosomes when eukaryotic cells face with nutrient starvation. In this review, we focus on the pre-autophagosomal structure (PAS), a functional entity responsible for autophagosome formation in Saccharomyces cerevisiae, and discuss its relevance to autophagy in mammalian cells.

Publication types

Review

MeSH terms

Animals
Autophagy* / genetics
Models, Biological
Phagosomes / metabolism*
Saccharomyces cerevisiae / cytology*
Saccharomyces cerevisiae / metabolism
Saccharomyces cerevisiae Proteins / metabolism

Substances

Saccharomyces cerevisiae Proteins