Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals tested for carcinogenicity by the U.S. National Toxicology Program

R W Tennant; J Ashby

doi:10.1016/0165-1110(91)90002-d

Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals tested for carcinogenicity by the U.S. National Toxicology Program

Mutat Res. 1991 May;257(3):209-27. doi: 10.1016/0165-1110(91)90002-d.

Authors

R W Tennant¹, J Ashby

Affiliation

¹ National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.

PMID: 2014033
DOI: 10.1016/0165-1110(91)90002-d

Abstract

This paper is an extension of compilations published previously in this journal. (Ashby and Tennant, 1988; Ashby et al., 1989). A summary of the rodent carcinogenicity bioassay data on a further 39 chemicals tested by the U.S. National Toxicology Program (NTP) is presented. An evaluation of each chemical for structural alerts to DNA-reactivity is also provided, together with a summary of its mutagenicity to Salmonella. Chemicals with an aliphatic nitro group (-C-NO2) have been added to the composite structure of DNA-reactive sub-groups. The 39 chemicals were numbered and evaluated as an extension of the earlier analysis of 264 NTP chemicals. The activity patterns and conclusions derived from the earlier studies are followed by these 39 chemicals, albeit a detailed analysis of the total database of 301 chemicals is reserved for the succeeding paper.

MeSH terms

Carcinogenicity Tests
Carcinogens*
DNA / drug effects
Information Systems
Mutagenicity Tests
Mutagens*
Salmonella typhimurium / genetics*
Structure-Activity Relationship

Substances

Carcinogens
Mutagens
DNA