Abstract
By use of the model virus, expressing the HCV envelope proteins E1 and E2, bioassay guided separation of the MeOH extract from Rosa rugosa Thunb. disclosed tellimagrandin I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure-activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1.
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemistry*
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology
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Biphenyl Compounds / chemistry
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Biphenyl Compounds / isolation & purification
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Biphenyl Compounds / pharmacology
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Gallic Acid / analogs & derivatives*
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Gallic Acid / chemistry
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Gallic Acid / isolation & purification
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Gallic Acid / pharmacology
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Glucosides / chemistry*
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Humans
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Rosaceae / chemistry*
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Structure-Activity Relationship
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Viral Envelope Proteins / antagonists & inhibitors
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Viral Envelope Proteins / metabolism*
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Virus Integration / drug effects*
Substances
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Antiviral Agents
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Biphenyl Compounds
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E1 protein, Hepatitis C virus
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Glucosides
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Viral Envelope Proteins
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glycoprotein E2, Hepatitis C virus
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eugeniin
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Gallic Acid
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casuarictin
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tellimagrandin I