Abstract
Endocannabinoids have been shown to activate reward-related feeding and to promote astrocytic differentiation. We investigated whether high-fat diet (HFD) intake produced a preference for HFD via an endocannabinoid-dependent mechanism. In the conditioned place preference test, the 2-week HFD-intake group showed preference for HFD and had increased expression of a marker for reactive astrocytes, glial fibrillary acid protein (GFAP), in the hypothalamus. The cannabinoid CB(1)-receptor antagonist O-2050 reduced the preference for HFD and expression of GFAP in the hypothalamus. These results suggested that HFD intake led to the development of a preference for HFD via astrocytic CB(1) receptors in the hypothalamus.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Astrocytes / drug effects*
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Astrocytes / metabolism
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Dietary Fats / administration & dosage*
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Dronabinol / analogs & derivatives*
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Dronabinol / pharmacology
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Feeding Behavior / drug effects
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Feeding Behavior / physiology
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Feeding Behavior / psychology
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Food Preferences / drug effects*
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Food Preferences / physiology
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Food Preferences / psychology
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Hypothalamus / cytology
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Hypothalamus / drug effects
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Hypothalamus / metabolism
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Male
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Mice
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Mice, Inbred ICR
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Pyrans / pharmacology*
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Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
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Receptor, Cannabinoid, CB1 / physiology
Substances
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(6aR,10aR)-3-(1-methansulfonylamino-4-hexyn-6-yl)6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo(b,d)pyran
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Dietary Fats
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Pyrans
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Receptor, Cannabinoid, CB1
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Dronabinol