Systemic lupus erythematosis is a complex multi-system autoimmune disorder that frequently requires both physical and psychological care from nurses working in non-specialist areas. Both primary and secondary care nurses should have a working knowledge of this unfamiliar condition, so that they may support the patient with SLE at whatever stage of their care pathway. This article seeks to outline the important principles in lupus management for the non-specialist nurse, and to give some pointers towards informed care.