Abstract
In this issue of Immunity, Ghisletti et al. (2010) examined lipopolysaccharide (LPS)-induced binding of the p300 transcription coactivator to identify inducible enhancers throughout the genome of mouse macrophages, thereby revealing common features of enhancers that contribute to the LPS response and a critical role for PU.1 in enhancer marking.
MeSH terms
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Animals
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E1A-Associated p300 Protein / genetics
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E1A-Associated p300 Protein / metabolism
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Gene Expression Regulation*
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Humans
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Inflammation / genetics
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Inflammation / immunology
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Inflammation / metabolism
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Lipopolysaccharides / immunology*
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Protein Binding
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / metabolism
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Regulatory Sequences, Nucleic Acid*
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Trans-Activators / genetics
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Trans-Activators / metabolism
Substances
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Lipopolysaccharides
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Proto-Oncogene Proteins
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Trans-Activators
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proto-oncogene protein Spi-1
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E1A-Associated p300 Protein
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Ep300 protein, mouse