Seq-ing LPS-induced enhancers

Immunity. 2010 Mar 26;32(3):296-8. doi: 10.1016/j.immuni.2010.03.011.

Abstract

In this issue of Immunity, Ghisletti et al. (2010) examined lipopolysaccharide (LPS)-induced binding of the p300 transcription coactivator to identify inducible enhancers throughout the genome of mouse macrophages, thereby revealing common features of enhancers that contribute to the LPS response and a critical role for PU.1 in enhancer marking.

Publication types

  • Comment

MeSH terms

  • Animals
  • E1A-Associated p300 Protein / genetics
  • E1A-Associated p300 Protein / metabolism
  • Gene Expression Regulation*
  • Humans
  • Inflammation / genetics
  • Inflammation / immunology
  • Inflammation / metabolism
  • Lipopolysaccharides / immunology*
  • Protein Binding
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism
  • Regulatory Sequences, Nucleic Acid*
  • Trans-Activators / genetics
  • Trans-Activators / metabolism

Substances

  • Lipopolysaccharides
  • Proto-Oncogene Proteins
  • Trans-Activators
  • proto-oncogene protein Spi-1
  • E1A-Associated p300 Protein
  • Ep300 protein, mouse