Abstract
Viral ion channels are short membrane proteins with 50-120 amino acids and play an important role either in regulating virus replication, such as virus entry, assembly and release or modulating the electrochemical balance in the subcellular compartments of host cells. This review summarizes the recent advances in viral encoded ion channel proteins (or viroporins), including PBCV-1 KcV, influenza M2, HIV-1 Vpu, HCV p7, picornavirus 2B, and coronavirus E and 3a. We focus on their function and mechanisms, and also discuss viral ion channel protein serving as a potential drug target.
2010 Elsevier B.V. All rights reserved.
MeSH terms
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Animals
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Antiviral Agents / pharmacology
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Host-Pathogen Interactions
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Human Immunodeficiency Virus Proteins / chemistry
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Human Immunodeficiency Virus Proteins / genetics
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Human Immunodeficiency Virus Proteins / metabolism
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Humans
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Ion Channels / chemistry*
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Ion Channels / drug effects
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Ion Channels / genetics
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Ion Channels / metabolism*
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Potassium Channels / chemistry
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Potassium Channels / genetics
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Potassium Channels / metabolism
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Viral Envelope Proteins / chemistry
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Viral Envelope Proteins / genetics
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Viral Envelope Proteins / metabolism
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Viral Matrix Proteins / chemistry
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Viral Matrix Proteins / genetics
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Viral Matrix Proteins / metabolism
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Viral Nonstructural Proteins / chemistry
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Viral Nonstructural Proteins / genetics
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Viral Nonstructural Proteins / metabolism
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Viral Proteins / chemistry*
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Viral Proteins / drug effects
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Viral Proteins / genetics
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Viral Proteins / metabolism*
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Viral Regulatory and Accessory Proteins / chemistry
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Viral Regulatory and Accessory Proteins / genetics
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Viral Regulatory and Accessory Proteins / metabolism
Substances
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2B protein, poliovirus
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Antiviral Agents
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Human Immunodeficiency Virus Proteins
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Ion Channels
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Kcv potassium channel, Chlorella virus
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M2 protein, Influenza A virus
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Potassium Channels
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Viral Envelope Proteins
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Viral Matrix Proteins
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Viral Nonstructural Proteins
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Viral Proteins
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Viral Regulatory and Accessory Proteins
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p7 protein, Hepatitis C virus
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vpu protein, Human immunodeficiency virus 1