Abstract
Since the discovery of noncoding small miRNAs and their function in controlling mRNA translational rate, the small non-coding miRNA world has become a research wonderland for cancer and other human diseases. Due to the critical regulatory function, miRNA can act as an oncogene or a tumor-suppressor gene. This review will cover some of the recent discoveries of the potential of miRNAs as cancer biomarkers in colorectal cancer, future challenges and solutions.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Biomarkers, Tumor / chemistry
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism*
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Colorectal Neoplasms / diagnosis*
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Colorectal Neoplasms / drug therapy
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Colorectal Neoplasms / genetics
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Colorectal Neoplasms / metabolism*
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Gene Expression Regulation, Neoplastic
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Humans
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MicroRNAs / chemistry
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MicroRNAs / genetics
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MicroRNAs / metabolism*
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Prognosis
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RNA Stability
Substances
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Biomarkers, Tumor
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MicroRNAs