Abstract
The effect on deamination of serotonine, dopamine, tiramine and 2-phenylamine of benzamide derivatives befol, moclobemide and LIS-641 was studied. Befol and moclobemide are inhibitors of serotonine deaminating activity of MAO. The different sensitivity of this activity to the effect of the benzamide derivatives in beef or rat brain and human placenta was noted. The inhibition was more distinct in tissue homogenate than in corresponding mitochondrial fractions.
MeSH terms
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Animals
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Antidepressive Agents / pharmacology*
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Benzamides / pharmacology*
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Blood Platelets / drug effects
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Blood Platelets / enzymology
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Brain / drug effects
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Brain / enzymology
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Cattle
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Female
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Humans
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Mitochondria / drug effects
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Mitochondria / enzymology
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Moclobemide
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Monoamine Oxidase / drug effects*
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Monoamine Oxidase / metabolism
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Morpholines / pharmacology*
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Placenta / drug effects
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Placenta / enzymology
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Rats
Substances
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Antidepressive Agents
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Benzamides
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Morpholines
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befol
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Monoamine Oxidase
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Moclobemide