Abstract
Natural products, especially microtubule-binding natural products, play important roles in the war against cancer. From the clinical use of vinblastine in 1961, paclitaxel in 1992, to ixabepilone in 2007, microtubule-binding natural products have continually contributed to the development of cancer therapy. The present review summarizes the development of representative microtubule-binding natural products including agents binding to the colchicine-binding site, the VINCA alkaloid-binding site, the taxane-binding site and other binding sites. Future directions for the development of new anticancer microtubule-binding natural products are discussed. Finding new formulations, new targets and new sources of microtubule-binding natural products may enable more members of this kind of agent to be introduced into the clinic for cancer therapy.
Georg Thieme Verlag KG Stuttgart-New York.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antineoplastic Agents, Phytogenic / adverse effects
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Binding Sites
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Bridged-Ring Compounds / metabolism
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Bridged-Ring Compounds / pharmacology
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Clinical Trials as Topic
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Colchicine / metabolism
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Colchicine / pharmacology
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Epothilones / metabolism
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Epothilones / pharmacology
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Epothilones / physiology
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Humans
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Microtubules / chemistry
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Microtubules / drug effects*
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Microtubules / physiology
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Microtubules / ultrastructure
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Neoplasms / drug therapy*
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Neoplasms / ultrastructure
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Taxoids / metabolism
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Taxoids / pharmacology
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Tubulin Modulators / adverse effects
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Tubulin Modulators / pharmacology
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Tubulin Modulators / therapeutic use*
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Vinca Alkaloids / metabolism
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Vinca Alkaloids / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Bridged-Ring Compounds
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Epothilones
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Taxoids
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Tubulin Modulators
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Vinca Alkaloids
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taxane
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Colchicine