MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity

Natalia J Martinez; Richard I Gregory

doi:10.1016/j.stem.2010.06.011

MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity

Cell Stem Cell. 2010 Jul 2;7(1):31-5. doi: 10.1016/j.stem.2010.06.011.

Authors

Natalia J Martinez¹, Richard I Gregory

Affiliation

¹ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard Stem Cell Institute, Children's Hospital Boston, Boston, MA 02115, USA.

Abstract

Understanding the molecular foundations of embryonic stem cell (ESC) self-renewal and pluripotency will facilitate therapeutic exploitation of these remarkable cells. Here we discuss the emerging roles of microRNAs in the establishment and maintenance of ESC identity and summarize our current understanding of the mechanisms controlling microRNA expression and function in ESCs.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Cycle / genetics
Cell Cycle / physiology
Cell Differentiation / genetics
Cell Differentiation / physiology
Embryonic Stem Cells / cytology
Embryonic Stem Cells / metabolism*
MicroRNAs / genetics
MicroRNAs / physiology*
Models, Biological
Signal Transduction / genetics
Signal Transduction / physiology*

Substances

MicroRNAs

Abstract

Publication types

MeSH terms

Substances

Grants and funding