Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci

Nat Genet. 2010 Aug;42(8):703-6. doi: 10.1038/ng.624. Epub 2010 Jul 11.

Abstract

Behçet's disease is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions. We conducted a genome-wide association study in a Japanese cohort including 612 individuals with Behçet's disease and 740 unaffected individuals (controls). We identified two suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2, rs12119179, P = 2.7 x 10(-8)) and 1q32.1 (IL10, rs1554286, P = 8.0 x 10(-8)). A meta-analysis of these two loci with results from additional Turkish and Korean cohorts showed genome-wide significant associations (rs1495965 in IL23R-IL12RB2, P = 1.9 x 10(-11), odds ratio = 1.35; rs1800871 in IL10, P = 1.0 x 10(-14), odds ratio = 1.45).

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Behcet Syndrome / genetics*
  • Case-Control Studies
  • Disease Susceptibility
  • Eye
  • Genome-Wide Association Study*
  • Humans
  • Interleukin-10 / genetics
  • Odds Ratio
  • Skin Diseases / genetics
  • Turkey

Substances

  • Interleukin-10