Inflammasome inhibition as a pathogenic stealth mechanism

Debra J Taxman; Max T-H Huang; Jenny P-Y Ting

doi:10.1016/j.chom.2010.06.005

Inflammasome inhibition as a pathogenic stealth mechanism

Cell Host Microbe. 2010 Jul 22;8(1):7-11. doi: 10.1016/j.chom.2010.06.005.

Authors

Debra J Taxman¹, Max T-H Huang, Jenny P-Y Ting

Affiliation

¹ Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.

Abstract

The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host defense against microbial pathogens. Recent discoveries have uncovered a plethora of pathogenic strategies to inhibit inflammasome-mediated processing of IL-1beta and IL-18. We review recent evidence for viral and bacterial manipulation of the inflammasome, ranging from perturbation of caspase-1 activation to targeting of specific inflammasome components.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Bacteria / immunology*
Bacteria / pathogenicity
Bacterial Infections / immunology*
Bacterial Infections / microbiology
Down-Regulation*
Host-Pathogen Interactions*
Humans
Virus Diseases / immunology*
Virus Diseases / virology
Viruses / immunology*
Viruses / pathogenicity

Abstract

Publication types

MeSH terms

Grants and funding