The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization

Arthur A M Wilde; Pieter G Postema; José M Di Diego; Sami Viskin; Hiroshi Morita; Jeffrey M Fish; Charles Antzelevitch

doi:10.1016/j.yjmcc.2010.07.012

The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization

J Mol Cell Cardiol. 2010 Oct;49(4):543-53. doi: 10.1016/j.yjmcc.2010.07.012. Epub 2010 Jul 24.

Authors

Arthur A M Wilde¹, Pieter G Postema, José M Di Diego, Sami Viskin, Hiroshi Morita, Jeffrey M Fish, Charles Antzelevitch

Affiliation

¹ Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.

Abstract

This Point/Counterpoint presents a scholarly debate of the mechanisms underlying the electrocardiographic and arrhythmic manifestations of Brugada syndrome (BrS), exploring in detail the available evidence in support of the repolarization vs. depolarization hypothesis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Arrhythmias, Cardiac / physiopathology
Brugada Syndrome / physiopathology*
Cardiac Electrophysiology / methods
Electrocardiography
Humans

Abstract

Publication types

MeSH terms

Grants and funding