A 6-month study of the effects of 0.3% triclosan/copolymer dentifrice on dental implants

J Clin Periodontol. 2011 Jan;38(1):33-42. doi: 10.1111/j.1600-051X.2010.01617.x. Epub 2010 Sep 13.

Abstract

Aim: Supportive therapy to maintain dental implants is increasingly important. This study examined the effect of a 0.3% triclosan/2% copolymer dentifrice on oral biofilms and gingival inflammation (GI) on dental implants and peri-implant tissues.

Materials and methods: One hundred and twenty adults with a dental implant and contra-lateral tooth were enrolled in this 6 month, double-blind, two-treatment, parallel group study. Sixty subjects were randomly assigned to a triclosan/copolymer dentifrice test group and 60 subjects to a fluoride dentifrice control group and instructed to brush twice daily for 6 months. At baseline, 3, and 6 months, a calibrated dentist assessed dental plaque, GI and collected supragingival dental plaque for microbiological analysis.

Results: Subjects in the triclosan/copolymer group demonstrated significantly lower levels of dental plaque, gingivitis, and bleeding on probing at 3 and 6 months at both the implant and contra-lateral tooth compared with the fluoride group (p<0.05). There were significantly fewer Gram-negative anaerobes in the triclosan/copolymer group (p<0.05) including >90% reductions in Aggregatibacter actinomycetemcomitans, Campylobacter rectus, Eubacterium saburreum, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella melaninogenica, Solobacterium moorei, and Tannerella forsythia.

Conclusions: Twice daily use of a triclosan/copolymer dentifrice may enhance dental implant maintenance by reducing dental plaque and GI.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Bacteria / drug effects
  • Biofilms / drug effects*
  • Colony Count, Microbial
  • DNA, Bacterial / analysis
  • Dental Implants / microbiology*
  • Dental Plaque / microbiology
  • Dental Plaque / prevention & control
  • Dentifrices / pharmacology
  • Dentifrices / therapeutic use*
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Fluorides / pharmacology
  • Fluorides / therapeutic use
  • Gingivitis / prevention & control*
  • Humans
  • Male
  • Maleates / pharmacology
  • Maleates / therapeutic use*
  • Middle Aged
  • Peri-Implantitis / prevention & control
  • Periodontal Index
  • Polyvinyls / pharmacology
  • Polyvinyls / therapeutic use*
  • Prosthesis-Related Infections / prevention & control
  • Triclosan / pharmacology
  • Triclosan / therapeutic use*
  • Young Adult

Substances

  • DNA, Bacterial
  • Dental Implants
  • Dentifrices
  • Drug Combinations
  • Maleates
  • Polyvinyls
  • polyvinylmethoxyethylene-maleic anhydride copolymer
  • Triclosan
  • Fluorides