A responsive europium(III) chelate that provides a direct readout of pH by MRI

Yunkou Wu; Todd C Soesbe; Garry E Kiefer; Piyu Zhao; A Dean Sherry

doi:10.1021/ja106018n

A responsive europium(III) chelate that provides a direct readout of pH by MRI

J Am Chem Soc. 2010 Oct 13;132(40):14002-3. doi: 10.1021/ja106018n.

Authors

Yunkou Wu¹, Todd C Soesbe, Garry E Kiefer, Piyu Zhao, A Dean Sherry

Affiliation

¹ Department of Chemistry, University of Texas at Dallas, P.O. Box 830668, Richardson, Texas 75083, USA.

Abstract

A europium(III) DO3A-tris(amide) complex is reported for imaging pH by MRI using ratiometric chemical exchange saturation transfer (CEST) principles. Deprotonation of a single phenolic proton between pH 6 and 7.6 results in an ∼5 ppm shift in the water exchange CEST peak that is easily detected by MRI. Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Chelating Agents / chemistry*
Europium / chemistry*
Hydrogen-Ion Concentration*
Magnetic Resonance Imaging / methods*

Substances

Chelating Agents
Europium

Abstract

Publication types

MeSH terms

Substances

Grants and funding