There has been a recent acceleration in the development and testing of programs for computer-assisted cognitive-behavioral therapy (CCBT). Programs are now available for treatment of depression, anxiety disorders, and other psychiatric conditions. Technology for delivery of CCBT includes multimedia programs, virtual reality, and handheld devices. Research on CCBT generally has supported the efficacy of computer-assisted therapy and has shown patient acceptance of computer tools for psychotherapy. Completion rates and treatment efficacy typically have been higher when clinicians prescribe and support the use of psychotherapeutic computer programs than when programs are delivered in a self-help format without clinician involvement. CCBT seems to have the potential to improve access to evidence-based therapies while reducing the demand for clinician time.