The authors report a novel case of solitary infantile myofibroma originating from the conjunctiva and encroaching over the limbus. This is an observational case report with clinicopathologic correlation. Immunostaining of the lesion was positive for vimentin and smooth muscle actin, and negative for pancytokeratin, desmin, myogenin, EMA, myoglobin, HMB45, and MelanA. To the authors' knowledge, this is the first reported case of myofibroma originating from the conjunctiva and this case highlights the importance of considering myofibromatosis in the differential diagnosis of unusual conjunctival lesions.
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