Abstract
Angiotensin II (Ang II) is a major contributor to the progression of renal fibrosis. Wang and colleagues provide evidence that signaling through the prolyl-4-hydroxylase domain (PHD)-hypoxia-inducible factor-1 (HIF-1) pathway mediates profibrotic effects of Ang II in rat renal medullary interstitial cells under normoxic conditions, thus placing the HIF oxygen-sensing pathway into the center of an Ang II-induced profibrotic signaling cascade.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Comment
MeSH terms
-
Actins / metabolism
-
Angiotensin II / administration & dosage
-
Angiotensin II / metabolism*
-
Animals
-
Basic Helix-Loop-Helix Transcription Factors / genetics
-
Basic Helix-Loop-Helix Transcription Factors / metabolism
-
Cell Transdifferentiation
-
Collagen Type I / metabolism
-
Collagen Type III / metabolism
-
Fibrosis
-
Humans
-
Hydrogen Peroxide / metabolism
-
Hypoxia-Inducible Factor 1, alpha Subunit / genetics
-
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
-
Kidney Medulla / metabolism*
-
Kidney Medulla / pathology
-
Procollagen-Proline Dioxygenase / genetics
-
Procollagen-Proline Dioxygenase / metabolism
-
Proliferating Cell Nuclear Antigen / metabolism
-
Rats
-
Tissue Inhibitor of Metalloproteinase-1 / metabolism
-
Up-Regulation
-
Vimentin / metabolism
Substances
-
Actins
-
Basic Helix-Loop-Helix Transcription Factors
-
Collagen Type I
-
Collagen Type III
-
Hypoxia-Inducible Factor 1, alpha Subunit
-
Proliferating Cell Nuclear Antigen
-
Tissue Inhibitor of Metalloproteinase-1
-
Vimentin
-
Angiotensin II
-
endothelial PAS domain-containing protein 1
-
Hydrogen Peroxide
-
Procollagen-Proline Dioxygenase