Abstract
Store-operated Ca(2+) entry is a process whereby the depletion of intracellular Ca(2+) stores signals the opening of plasma membrane Ca(2+) channels. It has long been thought that the main function of store-operated Ca(2+) entry was the replenishment of intracellular Ca(2+) stores following their discharge during intracellular Ca(2+) signaling. Recent results, however, suggest that the primary function of these channels may be to provide direct Ca(2+) signals to recipients localized to spatially restricted areas close to the sites of Ca(2+) entry in order to initiate specific signaling pathways.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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Animals
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Calcium / metabolism*
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Calcium Channels / physiology*
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Calcium Signaling / physiology
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Cell Adhesion Molecules / physiology
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Drosophila Proteins / physiology
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Humans
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Inositol 1,4,5-Trisphosphate Receptors / physiology
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Membrane Proteins / physiology
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ORAI1 Protein
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Stromal Interaction Molecule 2
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TRPC Cation Channels / physiology
Substances
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Calcium Channels
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Cell Adhesion Molecules
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Drosophila Proteins
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Inositol 1,4,5-Trisphosphate Receptors
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Membrane Proteins
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ORAI1 Protein
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STIM2 protein, human
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Stromal Interaction Molecule 2
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TRPC Cation Channels
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olf186-F protein, Drosophila
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Calcium