[Gender differences in action Fenotropil and its structural analog--compound RGPU-95 on anxiety-depressive behavior animals]

I N Tiurenkov; V V Bagmetova; A V Shishkina; V M Berestovitskaia; O S Vasil'eva; E S Ostrogliadov

[Gender differences in action Fenotropil and its structural analog--compound RGPU-95 on anxiety-depressive behavior animals]

Eksp Klin Farmakol. 2010 Nov;73(11):10-4.

[Article in Russian]

Authors

I N Tiurenkov, V V Bagmetova, A V Shishkina, V M Berestovitskaia, O S Vasil'eva, E S Ostrogliadov

PMID: 21254591

Abstract

Fenotropil and its structural analog--compound RGPU-95 to a greater extent reduce the severity of anxious and depressive behavior in male rats than in females. On expression of the anxiolytic compound RGPU-95 significantly exceeds Fenotropil, but inferior to Diazepam; of antidepressant activity--comparable to Melipramin and exceeds Fenotropil.

Publication types

English Abstract

MeSH terms

Animals
Anxiety / drug therapy
Anxiety / physiopathology*
Behavior, Animal / drug effects*
Depression / drug therapy
Depression / physiopathology*
Female
GABA Modulators / pharmacology*
Male
Rats
Rats, Wistar
Sex Characteristics*

Substances

GABA Modulators